Yes and no.
By living in better conditions we're not exposed to as many harmful viruses, bacteria & poisons as we used to be. And on those occasions when we are it's only for brief periods of time and not day after day, week after week, moth after month.
Not quite. It was long theorized that the Bubonic Plague has weakened greatly over the years, but when they dug it up and tested it, it was nearly identical to the modern versions. Now they believe the Black Plague was so fatal because of the widespread malnutrition across Europe and the Asia at the time. The fact they didn't understand the role of viruses or sanitation, and that people shat (past tense of shit) in the street and ate from copper plates only made these situations worse).
So yeah, living conditions make a world of difference. In the 1400s the Black death wiped out 1/3 of Europe, in WW I the Flu killed l% in Europe and America.
Also, the use of anti-bacterial wipes is worse than you propose. They don't eliminate any of the harmful bacteria, what they do is kill all the beneficial bacterial which help the digestive system and combat the more harmful ones.
Sejintenej, the 'keep the kids safe and indoors' movement is credited with creating the dramatic rise in allergies from a tiny percentage to a majority of the population. What's more, it's now been determined that the best approach to an allergy isn't to avoid it, but to eat small amounts repeatedly (hopefully with an Epi pen nearby, just in case).
Graybyrd, something like 70% of ALL antibiotic use is dedicated to growth stimulants, so it follows that they play a major role in antibiotic resistance, even though the meat contains NO antibiotics when it leaves the lot. However, farms and slaughter houses foster the presence of antibiotic resistance, when are then shipped around the globe.
Are we fucking geniuses or what?
Also, the problem with antibiotic resistance is the class of antibiotics we rely on. It's easy to grow. A better class of antibiotic can be grown in dirt, but it won't survive in a lab, so isn't used. What's more, the dirt variety doesn't promote resistance after prolonged exposure. In fact, there are so many types, all different classes in themselves, that a resistance to one wouldn't impact any others.
However, it's estimated we're anywhere from 15 to 50 years from developing a way to develop and sell this new/old type of antibiotic.
Another issue are disease we almost eradicated but didn't. We now have more (but less severe) cases of Whooping Cough because the inoculations we all received as children wear off and become worthless as we age. I caught the disease in middle school (7th grade), despite being fully immunized as a child. For 2 months I coughed like I had Emphysema, and the last month I'd cough for 5 minutes before throwing up, attended school the entire time, and not a single doctor would prescribe a Whooping Cough test or booster!