I was re-reading the William Redman Carter story by Lazlo Zalezac and, about a quarter of the way through the story, there is this passage:
William shook his head and said, "I agree with Doug on this issue. Not only is this country in a crisis of followership, but so is the whole world. I don't think we could wipe out Smallpox today like we did in the past. Individuals were vaccinated even though the vaccine had the potential for rather bad consequences for a small percentage of those who took it.
"Today, people won't accept the risks associated with the vaccine. Why? It would be viewed as too risky even though the consequences of the disease are so horrible. The chance to wipe out a horrible disease would never be taken."
Lazlo Zalezac. William Redman Carter (Kindle Locations 4913-4917). World Literature Company.
The story was posted in 2005, but I don't remember if the anti-vax folks were active much back then or not... Still, I found it an interesting prediction of the short-sighted idiots we are running in to when discussions turn to a Covid vaccine.