Lycanthropes are real and have begun openly serving in the US military. They posses enhanced physical strength but are still hampered by the classics like silver and the urge to Shift ever full moon. (Small nod to the repeal of DADT.)
A mutant strain of avian flu becomes a global pandemic which precipitates the start of World War III. A three way nuclear exchange further reduces the population of a world at war. American forces must work first to end the war then the survivors must rebuild from scratch while constantly guarding against attack from within and without.
